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Royal Society elects Carolina researcher


Oliver Smithies, excellence professor of pathology at the School of Medicine, has been elected a member of the Royal Society of London, the United Kingdom's equivalent of the National Academy of Sciences in the United States.

No more than six foreign members are elected annually "from among persons of the greatest eminence for their scientific discoveries and attainment," according to the society. Founded in 1660, the independent organization promotes natural and applied sciences.

A member of the University's Lineberger Comprehensive Cancer Center, Smithies was recognized for boosting knowledge of genes and genetic engineering and applying that knowledge in altering genes in useful ways. For example, using gene targeting, a technique he pioneered, he and colleagues have developed mice with mutations that model human genetic diseases such as cystic fibrosis and hardening of the arteries. Thousands of other researchers around the world have adopted his technique.

Now, the scientist is studying high blood pressure--a major human problem--by using genetically altered mice.

Smithies joined the pathology and laboratory medicine faculty in 1988 after working at the University of Wisconsin at Madison, where he held the Hilldale professorship, one of the most prestigious at Wisconsin.

He has earned many international, national and state awards, including two Gairdner awards, the Alfred P. Sloan Award of the General Motors Foundation, the Ciba Award of the American Heart Association, the Bristol Myers Squibb Award for cardiovascular and metabolic disease research and a North Carolina Award in Science.



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