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Grants go to AIDS and cancer research


AIDS specialists at the School of Medicine and researchers at the Lineberger Comprehensive Cancer Center will receive multi-million-dollar grants to bolster their research and services.

The School of Medicine will get $12.5 million from the National Institute of Allergy and Infectious Diseases over the next five years to continue its battle against AIDS.

Charles van der Horst and Joseph Eron, professor and associate professor of medicine, respectively, are leading the effort.

The money is part of $21 million in renewed national Adult AIDS Clinical Trials Group (AACTG) funding. It will support care for people living with AIDS across North Carolina and clinical trials that already have resulted in far more effective treatments and promise further medical progress, the physicians say. Duke University researchers will receive the balance.

The new federal funding reflects both the quality of AIDS research and treatment in North Carolina and the growing number of people infected with HIV -- the virus that causes AIDS -- in the region.

Lineberger Comprehensive Cancer Center has received a five-year, $25.3 million grant from the National Cancer Institute to renew support for its cancer research programs.

That's a 94 percent increase from the center's previous five-year grant, one of the largest increases ever awarded by the institute's cancer centers program. All of the funds will be used at the University, making this grant one of the largest ever awarded for research at Carolina.

To support an increase in clinical-trial patients and promote new studies of novel therapies, the institute is providing new funds for additional research nurses, analytical laboratories and statistical support.

The grant will create a new laboratory for the ultrasensitive assessment of DNA damage and repair that can detect the first molecular steps toward cancer, as well as the effects of efforts to reverse those steps, officials said.

Funds also will be provided for a laboratory to develop and study mouse models of human cancers that can be used to identify and test new opportunities for treatment and prevention, as well as for a facility to create viruses to deliver and target molecular-based treatments.

Funds also will establish or enlarge laboratories that help scientists and epidemiologists determine what genes predispose people to cancer and to understand the interplay among genetics, environmental exposures and lifestyle factors that may lead to cancer.


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